Georgiy Belogurov
Ph.D.

M.S.- Moscow State University, School of Chemistry, Russia, 1997

Ph.D. - University of Turku, Dept. of Biochemistry and Food Chemistry, Finland, 2005

Postdoc - Ohio State Univesity, Dept. of Microbiology, USA, 2006-2009

Principal investigator - University of Turku, Dept. of Biochemistry and Food Chemistry, Finland, 2009-

Research interests

Bacterial transcription, enzyme kinetics, protein chemistry, phylogenomics, membrane proteins
Address

University of Turku, Dept. of Biochemistry and Food Chemistry, Vatselankatu 2, Turku FIN-20014, Finland. E-mail: gebelo(at)utu.fi tel.: +358-2-333-6855

Affiliations

Academy of Finland Research Fellow
Turku Collegium for Science and Medicine
National Graduate School in Informational and Structural Biology
Systems Biology Research Program
Research

MULTISUBUNIT RNA POLYMERASE:
understanding the mechanistic essentials of transcription (RNAP group homepage)
Publications

Belogurov G. A., Sevostyanova A., Svetlov V., Artsimovitch I. (2010). Functional regions of the N-terminal domain of the antiterminator RfaH. Mol. Microbiol. 76 (2): 286-301 [PubMed]

Belogurov, G.A., Mooney, R.A. Svetlov, V., Landick, R., Artsimovitch, I. (2009) Functional specialization of transcription elongation factors. EMBO J. 28(2):112-22 [PubMed]

Belogurov, G.A., Vassylyeva, M.N. Sevostyanova, A., Xiang, A., Lira, R., Webber, S., Klyuyev, S., Artsimovitch, I., Vassylyev, D.G. (2009) Transcription inactivation through local refolding of the RNA polymerase structure. Nature 457(7227): 332-335 [PubMed]

Svetlov V., Belogurov G.A., Shabrova E., Vassylyev D.G., Artsimovitch I. (2007) Allosteric control of the RNA polymerase by the elongation factor RfaH. Nucleic Acids Res. 35(17):5694-705 [PubMed]

Jämsen J., Tuominen H., Salminen A., Belogurov G.A., Magretova N.N., Baykov A.A., Lahti R. (2007) A CBS domain-containing pyrophosphatase of Moorella thermoacetica is regulated by adenine nucleotides. Biochem J. 408(3):327-33 [PubMed]

Belogurov G. A., Vassylyeva M.N., Svetlov V., Klyuyev S., Grishin N.V., Vassylyev D.G., Artsimovitch I. (2007) Structural basis for converting a general transcription factor into an operon-specific virulence regulator. Mol Cell. 26(1):117-29 [PubMed]

Malinen A. M., Belogurov G. A., Baykov A. A., Lahti R. (2007) Na+-pyrophosphatase: a novel primary sodium pump. Biochemistry 46(30):8872-8 [PubMed]

Belogurov, G. A., Malinen, A. M., Turkina, M. V., Jalonen, U., Rytkönen, K., Baykov, A. A., Lahti, R. (2005) Membrane-bound pyrophosphatase of Thermotoga maritima requires sodium for activity. Biochemistry 44(6): 2088-2096 [PubMed]

Malinen, A. M., Belogurov, G. A., Salminen, M., Baykov, A. A. and Lahti, R. (2004) Elucidating the role of conserved glutamates in H+-pyrophosphatase of Rhodospirillum rubrum. J. Biol. Chem. 279: 26811-26816 [PubMed]

Belogurov, G. A. and Lahti, R. (2002) A Lysine substitute for K+: A460K mutation eliminates K+-dependence in H+-pyrophosphatase of Carboxydothermus hydrogenoformans. J. Biol. Chem. 277: 49651-49654 [PubMed]

Belogurov, G. A., Turkina, M. V., Penttinen, A., Huopalahti, S., Baykov, A. A. and Lahti, R. (2002) H+-Pyrophosphatase of Rhodospirillum rubrum: High-yield expression in Escherichia coli and identification of the Cys residues responsible for inactivation by mersalyl. J. Biol. Chem. 277: 22209-22214 [PubMed]

Belogurov G. A., Fabrichniy I. P., Pohjanjoki P., Kasho V. N., Lehtihuhta E., Turkina M. V., Cooperman B. S., Goldman A., Baykov A.A., Lahti R. (2000) Catalytically important ionizations along the reaction pathway of yeast pyrophosphatase. Biochemistry 39(45):13931-13938 [PubMed]